Estimation of the time fluctuation of polysynaptic responses evoked by constant spinal cord stimulation

Abstract Polysynaptic activity is necessary to engage the neural circuitry that controls motor behaviour and crucial recovery after spinal cord injury (SCI) [1]. responses can be elicited with stimulation, there are few reports on these types of in human electrophysiology, most them describing as constant fixed stimuli. However, we have observed fluctuate amplitude time. Amplitude variations analysed statistical methods. time fluctuations more complex due multiple parameters involved. This work describes a methodology analyse fluctuation each pulse. It based calculation signal temporal centroid, representing whole activity, weighted by its latency, single value. value then used model linear regression. The was verified an electromyography dataset from discomplete injured patient stimulation. parameter able follow small changes responses' distribution. Examples how centroid identify presented. Once fitted model, coefficient interneuron processing and, together metrics, characterise polysynaptic during application stimulation parameters.